Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy.
Identifieur interne : 000006 ( France/Analysis ); précédent : 000005; suivant : 000007Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy.
Auteurs : Fares Bassil [France] ; Arnaud Monvoisin [France] ; Marie-Helene Canron [France] ; Anne Vital [France] ; Wassilios G. Meissner [France] ; François Tison [France] ; Pierre-Olivier Fernagut [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
MSA is a sporadic progressive neurodegenerative disorder characterized by a variable combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. The pathological hallmark of MSA is the accumulation of alpha-synuclein aggregates in the cytoplasm of oligodendrocytes along with neuronal loss and neuroinflammation, as well as blood-brain barrier dysfunction and myelin deterioration. Matrix metalloproteinases are zinc-dependent endopeptidases involved in the remodeling of the extracellular matrix, demyelination, and blood-brain barrier permeability. Several lines of evidence indicate a role for these enzymes in various pathological processes, including stroke, multiple sclerosis, Parkinson's, and Alzheimer's disease.
DOI: 10.1002/mds.26329
PubMed: 26260627
Affiliations:
- France
- Aquitaine, Poitou-Charentes
- Bordeaux, Poitiers
- Université de Bordeaux, Université de Poitiers
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pubmed:26260627Le document en format XML
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The pathological hallmark of MSA is the accumulation of alpha-synuclein aggregates in the cytoplasm of oligodendrocytes along with neuronal loss and neuroinflammation, as well as blood-brain barrier dysfunction and myelin deterioration. Matrix metalloproteinases are zinc-dependent endopeptidases involved in the remodeling of the extracellular matrix, demyelination, and blood-brain barrier permeability. Several lines of evidence indicate a role for these enzymes in various pathological processes, including stroke, multiple sclerosis, Parkinson's, and Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Poitou-Charentes</li></region><settlement><li>Bordeaux</li><li>Poitiers</li></settlement><orgName><li>Université de Bordeaux</li><li>Université de Poitiers</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Bassil, Fares" sort="Bassil, Fares" uniqKey="Bassil F" first="Fares" last="Bassil">Fares Bassil</name></noRegion><name sortKey="Canron, Marie Helene" sort="Canron, Marie Helene" uniqKey="Canron M" first="Marie-Helene" last="Canron">Marie-Helene Canron</name><name sortKey="Fernagut, Pierre Olivier" sort="Fernagut, Pierre Olivier" uniqKey="Fernagut P" first="Pierre-Olivier" last="Fernagut">Pierre-Olivier Fernagut</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><name sortKey="Monvoisin, Arnaud" sort="Monvoisin, Arnaud" uniqKey="Monvoisin A" first="Arnaud" last="Monvoisin">Arnaud Monvoisin</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Vital, Anne" sort="Vital, Anne" uniqKey="Vital A" first="Anne" last="Vital">Anne Vital</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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